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M. Baudry, S. Etienne, M. Bruce, M. Palucki, E. Jacobsen and B. Malfroy, “Salen-Manganese Complexes Are Superoxide Dismutase-Mimics,” Biochemical and Biophysical Research Communications, Vol. 192, No. 2, 1993, pp. 964-968. doi:10.1006/bbrc.1993.1509

has been cited by the following article:

• TITLE: Synthesis of Some N-[(4-Substituted-1-Piperazinyl)-Oxo(Alkyl and Ethylcarbamoyl)]-3-(2-Thiophenyl)Acrylamides as Non-Steroidal Anti-Allergic and Anti-Inflammatory Agents

  AUTHORS: Osama I. Abd El-Salam, Ahmed M. Shalaby, Abdulah A. El-Sawy, Soha Elshihaby, Mohamed Abdulla

  KEYWORDS: Thiophene; Amino Acids; Piperazines; Anti-Allergy; Ant-Inflammatory

  JOURNAL NAME: Open Journal of Synthesis Theory and Applications, Vol.2 No.2, April 9, 2013

  ABSTRACT: An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new products 5a-u were synthesized starting from conjugated 2-thiopheneacrylic acid with amino acid esters3a-g followed by coupling of their acid derivatives4a-g with some piperazine segments, with the aim to increase their biological activities and decrease side effects. The anti-allergic and anti-inflammatory activities of the products were evaluated and promising results were obtained.