TITLE:
Synthesis of Some N-[(4-Substituted-1-Piperazinyl)-Oxo(Alkyl and Ethylcarbamoyl)]-3-(2-Thiophenyl)Acrylamides as Non-Steroidal Anti-Allergic and Anti-Inflammatory Agents
AUTHORS:
Osama I. Abd El-Salam, Ahmed M. Shalaby, Abdulah A. El-Sawy, Soha Elshihaby, Mohamed Abdulla
KEYWORDS:
Thiophene; Amino Acids; Piperazines; Anti-Allergy; Ant-Inflammatory
JOURNAL NAME:
Open Journal of Synthesis Theory and Applications,
Vol.2 No.2,
April
9,
2013
ABSTRACT: An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new products 5a-u were synthesized starting from conjugated 2-thiopheneacrylic acid with amino acid esters3a-g followed by coupling of their acid derivatives4a-g with some piperazine segments, with the aim to increase their biological activities and decrease side effects. The anti-allergic and anti-inflammatory activities of the products were evaluated and promising results were obtained.