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Apopa, P.L., Qian, Y., Shao, R., Guo, N.L., Schwegler-Berry, D., Pacurari, M., Porter, D., Xianglin, S., Vallyathan, V., Castranova, V. and Flynn, D.C. (2009) Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodelling. Part Fibre Toxicol, 6:1.

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• TITLE: Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells

  AUTHORS: Daniel Moersdorf, Pierre Hugounenq, Lai Truonc Phuoc, Hind Mamlouk-Chaouachi, Delphine Felder-Flesch, Sylvie Begin-Colin, Geneviève Pourroy, Ingolf Bernhardt

  KEYWORDS: Red Blood Cells; Caco-2 Cells; Ca2+ Content; Intracellular PH; Magnetic Iron Oxide Nanoparticles

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.1 No.5, December 30, 2010

  ABSTRACT: The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.