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Geiser, M., Rothen-Rutishauser, B., Kapp, N., Schürch, S., Kreyling, W., Schulz, H., Semmler, M., Im Hof, V., Heyder, J. and Gehr, P. (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect, 113, 1555-1560.

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• TITLE: Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells

  AUTHORS: Daniel Moersdorf, Pierre Hugounenq, Lai Truonc Phuoc, Hind Mamlouk-Chaouachi, Delphine Felder-Flesch, Sylvie Begin-Colin, Geneviève Pourroy, Ingolf Bernhardt

  KEYWORDS: Red Blood Cells; Caco-2 Cells; Ca2+ Content; Intracellular PH; Magnetic Iron Oxide Nanoparticles

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.1 No.5, December 30, 2010

  ABSTRACT: The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.