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P. Sonnet, P. Dallemagne, J. Guillom, C. Engueard, S. Stiebing, J. Tangue, B. Bureau, S. Rault, P. Auvray, S. Moslemi, P. Sourdaine and G. E. Seralini, “New Aromatase Inhibitors. Synthesis and Biological Activity of Aryl-Substituted Pyrrolizine and Indolizine Derivatives,” Bioorganic & Medicinal Chemistry, Vol. 8, No. 5, 2000, pp. 945-955. doi:10.1016/S0968-0896(00)00024-9

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• TITLE: Spectral Analysis and Crystal Structure of Spiro[2.2”] Acenaphthene-1”-One-Spiro[3.3’]-5’-(2,3-Dichlorophenyl Methylidene)-1’-Methylpiperidin-4’-One-4- (2,3-Dichlorophenyl) Octahydroindolizine

  AUTHORS: Rakkappan Vishnu Priya, Janakiraman Suresh, Sathiyamoorthi Sivakumar, Raju Ranjith Kumar

  KEYWORDS: Single Crystal Structure; Conformation; Hydrogen Bond; NMR Spectra

  JOURNAL NAME: Crystal Structure Theory and Applications, Vol.1 No.3, December 31, 2012

  ABSTRACT: The crystal structure of spiro[2.2”]acenaphthene-1”-onespiro[3.3’]-5’-(2,3-dichlorophenylmethylidene)-1’-methylpipe-ridin-4’-one-4-(2,3-dichorophenyl) octahydroindolizine was elucidated by single crystal X ray diffraction. The title compound C37H30Cl4N2O2, crystallizes in the orthorhombic system, space group P212121 with a = 8.4610(4) , b = 16.0926(6) , c= 23.8997(11) and Z = 4. The central piperidine ring adopts twisted conformation, the piperidine of octahydroindolizine ring is in chair conformation and the pyrrole ring is in slightly twisted envelope conformation. Details of the synthesis, NMR, crystal structure determination and intra- and inter- molecular interactions of the compound are given.