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Engelhart, M.J., Geerlings, M.I., Meijer, J., Kiliaan, A., Ruitenberg, A., van Swieten, J.C., Stijnen, T., Hofman, A., Witteman, J.C.M. and Breteler, M.M.B. (2004) Inflammatory proteins in plasma and the risk of dementia: The Rotterdam study. Archives of Neurology, 61, 668-672. doi:10.1001/archneur.61.5.668

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• TITLE: Comparison of protein concentrations in serum versus plasma from Alzheimer’s patients

  AUTHORS: Ryan M. Huebinger, Guanghua Xiao, Kirk C. Wilhelmsen, Ramon Diaz-Arrastia, Fan Zhang, Sid E. O'Bryant, Robert C. Barber

  KEYWORDS: Alzheimer’s Disease; Serum Proteins; Plasma Proteins

  JOURNAL NAME: Advances in Alzheimer's Disease, Vol.1 No.3, December 28, 2012

  ABSTRACT: Background: There is great interest in developing blood-based biomarkers for Alzheimer’s disease (AD); however, there is no consensus as to what blood fraction is most appropriate for analyzing particular markers. The current study provides empirical evidence regarding how blood-based proteins vary depending on whether they are assayed in serum or plasma. Methods: Weanalyzed concentrations of 100 proteins in matched samples of serum and plasma from 39 Caucasian AD participants from the Texas Alzheimer’s Research and Care Consortium bymultiplex immunoassay. Results: Concentrations of 40 proteins were highly correlated (r2≥ 0.75) between plasma and serum while the remaining proteins were moderately to weakly correlated (r2