TITLE:
Spatial structure of beta-amyloid Aβ1-40 in complex with a biological membrane model
AUTHORS:
Konstantin S. Usachev, Andrey V. Filippov, Oleg N. Antzutkin, Vladimir V. Klochkov
KEYWORDS:
1H NMR; Two-Dimensional NMR (TOCSY, NOESY) Spectroscopy; Alzheimer’s Disease; Beta-Amyloid; Oligopeptides; Micelle
JOURNAL NAME:
Advances in Alzheimer's Disease,
Vol.1 No.3,
December
21,
2012
ABSTRACT: The spatial structure of beta-amyloid Aβ1-40 in complex with sodium dodecyl sulfate micelles as a model membrane system was investigated by 1H-1H two-dimensional NMR (TOCSY, NOESY) spectroscopy and molecular dynamic method calculations. On the basis of NOE and chemical shifts changes data, spatial structure of the complex beta-amyloid-model of the cell surface membrane was obtained.