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Jain, S., Filipe, M.I., Hall, P.A., Waseem, N., Lane, D.P. and Levison, D.A. (1991) Prognostic value of proliferating cell nuclear antigen in gastric carcinoma. Journal of Clinical Pathology, 44, 655-659. doi:10.1136/jcp.44.8.655

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• TITLE: Expression of PCNA in oral gingival epithelium of aggressive and, chronic periodontitis—A pilot study

  AUTHORS: Penapy Jyostna, Manchala Sesha Reddy, Manyam Ravikanth, Mandalapu Narendra, Chini Dorasani Dwarakanath

  KEYWORDS: Immunohistochemistry; Normal Gingiva; Aggressive Periodontitis; Chronic Periodontitis; Mitotic Index; Proliferating Cell Nuclear Antigen

  JOURNAL NAME: Open Journal of Stomatology, Vol.3 No.1, March 29, 2013

  ABSTRACT: Periodontal disease leads to loss of tissue homeostasis of tooth supporting structures. The mechanism of fibrous tissue degradation by various enzymes in chronic periodontitis and aggressive periodontitis was well documented but there is paucity of information regarding epithelial response. The aim of the present study was to evaluation of epithelial cell proliferation in Chronic Periodontitis, Aggressive Periodontitis and normal patients using Proliferating Cell Nuclear Antigen (PCNA). The study consists of 30 individuals who attended the Periodontia clinic of Vishnu Dental College. They were divided equally into 3 groups: chronic periodontitis (10) aggressive periodontitis (10) and normal individuals requiring gingival excision for crown lengthening (10). Excised gingival tissues were routinely processed and subjected to Immuno-histochemical evaluation using Proliferating Cell Nuclear Antigen (PCNA). The mean proliferation index was almost equal in Aggressive periodontitis patients (36.55) and normal individuals (37.02) but it was high in Aggressive Periodontitis patients when compared to chronic periodontitis group (18.86). Observations of this study indicate the possibility of subclinical inflammation in clinically normal gingiva and difference in the types of microorganism associated with chronic periodontitis and aggressive periodontitis.