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Mankodi, S., Bauroth, K., Witt, J.J., Bsoul, S., He, T., Gibb, R., Dunavent, J. and Hamilton, A. (2005) A 6month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque. American Journal of Dentistry, 18, 9A-14A.

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• TITLE: An in vitro study of antimicrobial agents incorporated into interim restorative materials

  AUTHORS: Arely Denisse Garza Garza, Violet I. Haraszthy, Jane D. Brewer, Edward Monaco, Jennifer Kuracina, Joseph J. Zambon

  KEYWORDS: Interim Restorations; Bis-Acryl Resin; Triclosan; Cetylpyridinium Chloride

  JOURNAL NAME: Open Journal of Stomatology, Vol.3 No.1, March 29, 2013

  ABSTRACT: Aim: To test the hypothesis that antimicrobial agents can be incorporated into bis-acryl resin and that the material will inhibit bacterial growth in vitro. Materials and Methods: 0.5%, 1% and 2% triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) and 0.05% 0.01% and 0.15% cetylpyridinium chloride were incorporated into bis-acryl resins and molded into 1 mm × 10 mm discs. The discs were placed on bacterial culture media inoculated with Aggregatibacter actinomycetemcomitans strain Y4, Porphyromonas gingivalis strain SUNYaB A7A1-28 or Streptococcus gordonii strain 10558, incubated and examined for growth inhibition. Results: Triclosan-containing bisacryl resin discs produced dose-dependent zones of growth inhibition for A. actinomycetemcomitans but not S. gordonii or P. gingivalis. Cetylpyridinium chloride-containing discs produced dose-dependent zones of growth inhibition for Porphyromonas gingivalis and Streptococcus gordonii but not A. actinomycetemcomitans. Conclusion: Triclosan and cetylpyridinium chloride can be incorporated into bis-acryl resin and can inhibit the growth of plaque bacteria in a dose dependent manner. Bis-acryl resin containing antimicrobial agents may inhibit in vivo plaque accumulation and gingival inflammation.