TITLE:
Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen
AUTHORS:
David C. Pryde, Thien-Duc Tran, Mark Gardner, Chris Pickford, Stephen M. Shaw, Mike Westby, Tanya Parkinson, Caroline Smith-Burchnell, Rob Webster, Satish Dayal
KEYWORDS:
HCV; Replicon; Antiviral; Cell-Based Screen
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.3 No.1,
March
29,
2013
ABSTRACT: A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were further evaluated, leading to the identification of a series of pyrrolopyridines with excellent antiviral activity in a fully infectious HCV cell-based assay and pharmacokinetic properties.