TITLE:
Quantitative determination of residual 2-(2-chloroethoxy) ethanol (CEE) in quetiapine fumarate by gas chromatogaraphy
AUTHORS:
Pravish Tiwari, Ravi Yadav, Padmakar A. Sathe, Deepali Gangrade
KEYWORDS:
GC; 2-(2-Chloroethoxy) Ethanol
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.1 No.5,
December
30,
2010
ABSTRACT: A simple and specific gas chromatographic method developed and validated for the determination of 2-(2-chloroethoxy) ethanol in Quetiapine Fumarate. The method is carried out with a flame ionization detector and DB-FFAP capillary column. The linearity was established over a range of 40-150 µg ml-1 and correlation coefficient is more than 0.999.