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Fine, D.H., Furgang, D., Markowitz, K., Sreenivasan, P.K., Klimpel, K. and De Vizio, W. (2006) The anti microbial effect of a triclosan/copolymer dentifrice on oral microorganisms in vivo. Journal of the American Dental Association, 137, 1406-1413.

has been cited by the following article:

• TITLE: Efficacy of a triclosan/copolymer dentifrice and a toothbrush with tongue cleaner in the treatment of oral malodor: A monadic clinical trial

  AUTHORS: Prem K. Sreenivasan, Violet I. Haraszthy, Joseph J. Zambon, William DeVizio

  KEYWORDS: Halitosis; Oral Malodor; Triclosan; Tongue

  JOURNAL NAME: Open Journal of Stomatology, Vol.3 No.1, March 29, 2013

  ABSTRACT: Aim: Oral malodor (halitosis) is a widespread condition caused by oral bacteria, particularly sulfur compound-producing species. This study assessed the effect of a triclosan/copolymer-containing dentifrice and a novel toothbrush with attached tongue cleaner on oral malodor and on the bacteria colonizing the dorsal surface of the tongue. Materials and Methods: 14 adult subjects with oral malodor defined as organoleptic scores ≥ 3 (scale 0 - 5) and mouth air sulfur levels ≥ 250 ppb participated in this study. Subjects were examined at baseline and after 28 days use of the triclosan dentifrice and toothbrush/tongue cleaner for: 1) organoleptic assessment; 2) mouth air sulfur levels; 3) tongue coating; and, 4) dorsal tongue surface microorganisms. Total bacterial numbers were assayed by microscopy. Dot-blot hybridization was used to assess a panel of 20 oral bacteria. Results: After 28 days, all subjects had significantly reduced organoleptic scores and mouth air sulfur levels compared to baseline (p 70% reduction in microbial numbers (p Enterococcus faecalis (p Peptostreptococcus micros (p Prevotella melaninogenica (p Porphyromonas gingivalis (p Solobacterium moorei (p