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P. L. Privalov. Stability of proteins, “Proteins Which Do Not Present a Single Cooperative System,” Advances in Protein Chemistry, Vol. 35, 1982, pp. 1-104. doi:10.1016/S0065-3233(08)60468-4

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• TITLE: Mechanisms of Action of Noninvasive Monopolar Radiofrequency: Technology Review

  AUTHORS: Terry L. Whipple, Scott P. Steinmann

  KEYWORDS: Thermal Shrinkage; Thermoplasty; Heat-Shock; AT2, Radiofrequency; Collagen Denaturation; Tendinosis; Wound Healing Response; Tendinopathy; Microtenotomy; Antinociceptive

  JOURNAL NAME: Open Journal of Orthopedics, Vol.3 No.1, March 29, 2013

  ABSTRACT: Tendinosis is now understood as the result of a failed tendon healing process regardless of where it occurs in the body. Current noninvasive therapeutic alternatives are anti-inflammatory in nature and outcomes are unpredictable at best. The benefit of invasive alternatives resides in the induction of the healing response as demonstrated in pre-clinical and clinical studies in cardiology and orthopaedics. A new technology that employs noninvasivemonopolar capacitive-coupled radiofrequency (mcRF), has demonstrated the ability to raise temperatures in tendons and ligaments upwards of 50°C, the temperature threshold for collagen modulation and recruitment of macrophages, fibroblasts and Heat Shock Protein factors—without damaging the overlying structures—resulting in activation of the Wound Healing Response (WHR).