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Min, B.-M., You,Y., Kim, J.-M., at el. (2004) Formation of nanostructured poly(lactic-co-glycolic acid)/chitin matrix and its cellular response to normal human keratinocytes and fibroblasts. Carbohydrate Polymers, 57, 285-292.

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• TITLE: Fabrication and characterization of cross-linked gelatin electro-spun nano-fibers

  AUTHORS: Thi-Hiep Nguyen, Byong-Taek Lee

  KEYWORDS: Gelatin, Cross-Linking, Glutaraldehyde

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.3 No.12, December 30, 2010

  ABSTRACT: In this study, we developed a fast, simple and novel process to fabricate cross-linked electro-spun gelatin with limited amounts of glutaraldehyde (GA) using trifluoroacetic acid (TFA) as the solvent. Using SEM, the uncross-linked gelatin fibers were determined to have diameters between 50-300 nm, while the cross-linked gelatin electro-spun fibers had diameters between 100-500 nm. FT-IR revealed that the un-cross-linked and cross-linked electro-spun gelatin was fabricated successfully by electro-spinning using TFA as a solvent, which has not been reported until now. Stress-strain curves showed that the addition of small amounts of GA increased the strength of the gelatin by two fold and allowed for the creation of a water insoluble gelatin electro-spun membrane.