Article citationsMore>>

E. J. Lamb, M. C. Webb, D. E. Simpson, A. J. Coakley, D. J. Newman and S. E. O’Riordan, “Estimation of GFR in Older Patients with Chronic Renal Insfufficiency: Is the MDRD Formula an Improvement,” Journal of the American Geriatrics Society, Vol. 51, No. 7, 2003, pp. 1012- 1017. doi:10.1046/j.1365-2389.2003.51330.x

has been cited by the following article:

• TITLE: Estimation of GFR by MDRD Formula and Its Correlation to Cockcroft-Gault Equation in Five Stages of Chronic Kidney Disease

  AUTHORS: Absar Ali, Naila Asif, Zunaira Rais

  KEYWORDS: MDRD; Cockcroft-Gault; Chronic Kidney Disease; CKD

  JOURNAL NAME: Open Journal of Nephrology, Vol.3 No.1, March 27, 2013

  ABSTRACT: Background: Purpose of our study was to find out correlation between estimated Glomerular Filtration Rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula and Glomerular Filtration Rate by Cockcroft-Gault equations, in patients with chronic kidney disease (CKD), and to see whether they can be used interchangeably. Methods: We conducted a cross section study of 70 patients presented to the nephrology clinic over a period of one year. We compared the Glomerular Filtration Rate by these two formulas in five stages of Chronic Kidney Disease. Abbreviated 4 variable Modification of Diet in Renal Disease formula was used.Results: Age range was 15 - 79 years; Male 49%, Female 51%. The correlation (r) between eGFR by MDRD and eGFR by Cockcroft-Gault equation for CKD stages 1 to 5 was 0.64; 0.31; 0.32; 0.67; and 0.45 respectively. The correlation (r) between creatinine clearance by 24 hour urine collection and MDRD formula was 0.84 (P: 0.001). The correlation (r) between creatinine clearance by 24 hour urine collection Cockcroft-Gault equation was 0.79 (P: 0.001). Conclusion: We conclude that Cockcroft-Gault equation correlates best with MDRD formula at CKD stages 4 and one. Cockcroft-Gault equation underestimated eGFR in stages 1, 2 and 3 of chronic Kidney Disease.