Article citationsMore>>

X. Wang, J. Lewis, L. Appel, D. Cheek, G. Contreras, M. Faulkner, et al., “Validation of Creatinine Based Estimates of GFR When Evaluating Risk Factors in Longitudinal Studies of Kidney Disease,” Journal of the American Society of Nephrology, Vol. 17, No. 10, 2006, pp. 2900-2909. doi:10.1681/ASN.2005101106

has been cited by the following article:

• TITLE: Estimation of GFR by MDRD Formula and Its Correlation to Cockcroft-Gault Equation in Five Stages of Chronic Kidney Disease

  AUTHORS: Absar Ali, Naila Asif, Zunaira Rais

  KEYWORDS: MDRD; Cockcroft-Gault; Chronic Kidney Disease; CKD

  JOURNAL NAME: Open Journal of Nephrology, Vol.3 No.1, March 27, 2013

  ABSTRACT: Background: Purpose of our study was to find out correlation between estimated Glomerular Filtration Rate (GFR) by Modification of Diet in Renal Disease (MDRD) formula and Glomerular Filtration Rate by Cockcroft-Gault equations, in patients with chronic kidney disease (CKD), and to see whether they can be used interchangeably. Methods: We conducted a cross section study of 70 patients presented to the nephrology clinic over a period of one year. We compared the Glomerular Filtration Rate by these two formulas in five stages of Chronic Kidney Disease. Abbreviated 4 variable Modification of Diet in Renal Disease formula was used.Results: Age range was 15 - 79 years; Male 49%, Female 51%. The correlation (r) between eGFR by MDRD and eGFR by Cockcroft-Gault equation for CKD stages 1 to 5 was 0.64; 0.31; 0.32; 0.67; and 0.45 respectively. The correlation (r) between creatinine clearance by 24 hour urine collection and MDRD formula was 0.84 (P: 0.001). The correlation (r) between creatinine clearance by 24 hour urine collection Cockcroft-Gault equation was 0.79 (P: 0.001). Conclusion: We conclude that Cockcroft-Gault equation correlates best with MDRD formula at CKD stages 4 and one. Cockcroft-Gault equation underestimated eGFR in stages 1, 2 and 3 of chronic Kidney Disease.