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Toperoff, G., Aran, D., Kark, J.D., Rosenberg, M., Dubnikov, T., Nissan, B., Wainstein, J., Friedlander, Y., Levy-Lahad, E., Glaser, B. and Hellman, A. (2012) Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Human Molecular Genetics, 21, 371-383. doi:10.1093/hmg/ddr472

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• TITLE: FTO genotype is associated with body mass index and waist circumference in Mexican young adults

  AUTHORS: Margarita Teran-Garcia, Itzel Vazquez-Vidal, Flavia C. D. Andrade, Michelle Mosley, Eduardo Medina-Cerda, Celia Aradillas-Garcia

  KEYWORDS: FTO; Obesity; Genetic Risk; Young; Mexicans

  JOURNAL NAME: Open Journal of Genetics, Vol.3 No.1, March 26, 2013

  ABSTRACT: Individual variations in the fat mass and obesity-associated (FTO) gene have been associated with obesity and BMI in diverse populations, but there are no reports in young Mexicans. We explored the association of a common FTO single-nucleotide polymorphism (SNP, rs805704) with obesity-related phenotypes in Mexican young adults. The FTO-SNP was genotyped using the fluorescent polarization method in college-age, apparently healthy subjects from the “UP AMIGOS” cohort (n = 251, 18 - 25 yrs). Homozygotes for the A allele (15%, n = 38) were heavier (1.6 kg/m2 and6.2 kg) and had a larger waist circumference (WC,4.8 cm) than G allele carriers. The FTO genotype was associated with BMI, weight and WC independently of age and sex and explained 2.7 to 3.1% of the variance in obesity-related phenotypes. The FTO genotype was also associated with fasting glucose (P = 0.0283). No other associations were found in the additive model. Despite our small sample size, we found that the FTO-rs805704 genotype influences obesity-related phenotypes young Mexicans. Previously observed FTO associations with fasting glucose were replicated. Previously reported associations with other metabolic traits likely represent the long-term consequences of obesity.