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Adamson, A.L., Darr, D., Holley-Guthrie, E., Johnson, R.A., Mauser, A., Swenson, J. and Kenney, S. (2000) Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 activate the ATF2 transcription factor by increasing the levels of phosphorylated p38 and c-Jun Nterminal kinases. Journal of Virology, 74, 1224-1233. doi:10.1128/JVI.74.3.1224-1233.2000

has been cited by the following article:

• TITLE: Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity

  AUTHORS: Amy L. Adamson

  KEYWORDS: Epstein-Barr Virus; BZLF1; Drosophila; CG9384; Gnt-IVb

  JOURNAL NAME: Open Journal of Genetics, Vol.3 No.1, March 26, 2013

  ABSTRACT: Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world’s adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in Drosophila melanogaster to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the Drosophila melanogaster CG9384 gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication.