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McQuilton, P., St. Pierre, S.E., Thurmond, J. and Consortium, T.F. (2012) FlyBase 101—The basics of navigating FlyBase. Nucleic Acids Research, 40, D706-D714. doi:10.1093/nar/gkr1030

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• TITLE: Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity

  AUTHORS: Amy L. Adamson

  KEYWORDS: Epstein-Barr Virus; BZLF1; Drosophila; CG9384; Gnt-IVb

  JOURNAL NAME: Open Journal of Genetics, Vol.3 No.1, March 26, 2013

  ABSTRACT: Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world’s adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in Drosophila melanogaster to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the Drosophila melanogaster CG9384 gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication.