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D’Arrigo, A., Belluco, C., Ambrosi, A., Digito, M., Esposito, G., Bertola, A., Fabris, M., Nofrate, V., Mammano, E., Leon, A., Nitti, D. and Lise, M. (2005) Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. International Journal of Cancer, 115, 256-262. doi:10.1002/ijc.20883

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• TITLE: Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity

  AUTHORS: Amy L. Adamson

  KEYWORDS: Epstein-Barr Virus; BZLF1; Drosophila; CG9384; Gnt-IVb

  JOURNAL NAME: Open Journal of Genetics, Vol.3 No.1, March 26, 2013

  ABSTRACT: Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world’s adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in Drosophila melanogaster to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the Drosophila melanogaster CG9384 gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication.