Article citationsMore>>

W. H. Wilson, et al., “Navitoclax, a Targeted High-Affinity Inhibitor of BCL-2, in Lymphoid Malignancies: A Phase 1 Dose-Escalation Study of Safety, Pharmacokinetics, Pharmacodynamics, and Antitumour Activity,” The Lancet Oncology, Vol. 11, No. 12, 2010, pp. 1149-1159. doi:10.1016/S1470-2045(10)70261-8

has been cited by the following article:

• TITLE: Emerging Frontiers in Therapeutics of Diffuse Large B Cell Lymphoma: Epigenetics and B Cell Receptor Signaling

  AUTHORS: Soham Puvvada, Lisa Rimsza

  KEYWORDS: BCR Signaling; Epigenetics

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.3A, March 25, 2013

  ABSTRACT: This review discusses the impact of gene expression profiling and sequencing discoveries on new therapeutic strategies in Non-Hodgkin Lymphomas, particularly Diffuse Large B cell Lymphoma. Alterations in oncogenes, over-active signaling pathways down-stream of the B cell receptor, and epigenetic gene mutations will be described. We will also review new targeting strategies aimed at each of these aspects of cell biology encompassing BCL2, BTK, PKCβ, PI3K/mTOR and HDAC inhibition. Specific new drugs in clinical trials and early trial results are included as well.