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J. R. Brown, “Obatoclax in Combination with Fludarabine and Rituximab (FR) Is Well Tolerated and Shows Promising Clinical Activity in Relapsed CLL/SLL,” Blood, Vol. 118, No. 21, 2012, Abstract No: 2865.

has been cited by the following article:

• TITLE: Emerging Frontiers in Therapeutics of Diffuse Large B Cell Lymphoma: Epigenetics and B Cell Receptor Signaling

  AUTHORS: Soham Puvvada, Lisa Rimsza

  KEYWORDS: BCR Signaling; Epigenetics

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.3A, March 25, 2013

  ABSTRACT: This review discusses the impact of gene expression profiling and sequencing discoveries on new therapeutic strategies in Non-Hodgkin Lymphomas, particularly Diffuse Large B cell Lymphoma. Alterations in oncogenes, over-active signaling pathways down-stream of the B cell receptor, and epigenetic gene mutations will be described. We will also review new targeting strategies aimed at each of these aspects of cell biology encompassing BCL2, BTK, PKCβ, PI3K/mTOR and HDAC inhibition. Specific new drugs in clinical trials and early trial results are included as well.