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Vassallo, R., Kroening, P.R., Parambil, J. and Kita, H. (2008) Nicotine and oxidative cigarette smoke constituents induce immune-modulatory and pro-inflammatory dendritic cell responses. Molecular Immunology, 45, 3321-3329. doi:10.1016/j.molimm.2008.04.014

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• TITLE: Serum myeloperoxidase level is increased in heavy smokers

  AUTHORS: André B. Martins, Valdecir F. Ximenes, Luiz Marcos da Fonseca

  KEYWORDS: Smokers; Neutrophils; IL-8;Myeloperoxidase; Hypochlorous Acid; Atherosclerosis

  JOURNAL NAME: Open Journal of Clinical Diagnostics, Vol.3 No.1, March 20, 2013

  ABSTRACT: Raised myeloperoxidase (MPO) serum levels are associated with endothelial dysfunction and cigarette smoking is a risk factor for cardiovascular diseases. Since myocardial infarction is associated with leukocytosis and smokers present increased levels of neutrophils, here we hypothesized that the levels of serum MPO in smokers could be also raised. We carried out a study on sixty eight adult healthy volunteers. The control group consisted of thirty four non-smokers and the test group was thirty four heavy smokers. The hemogram, interleukin-8 (IL-8) and MPO serum levels were measured. Neutrophil, monocyte and lymphocyte counts were higher (p