TITLE:
Combination Lipid Therapy on Lipid Profiles in Patients with Impaired Glucose Tolerance
AUTHORS:
Hiroaki Kawano, Yasuhiro Nagayoshi, Hisao Ogawa, Yoshihiro Kinoshita
KEYWORDS:
Statins; Fibrates; Dyslipidemia
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.4 No.3,
March
22,
2013
ABSTRACT: Objective: This study compared the effects of combination statin and fibrate therapy with either
statin or fibrate monotherapy on lipid profiles in patients with impaired
glucose tolerance (IGT) and a high risk for cardiovascular disease. Methods & Patients: Forty-five
patients with IGT and dyslipidemia (men 25, women 20, mean age 61.7 ± 2.4 yrs) were assigned randomly to
the 3 treatment groups for a 6-month period. Results: After 6 months of treatment, low density lipoprotein
levels decreased in every group, especially the statin and statin + fibrate groups. Triglyceride levels
also decreased in all three groups, especially the fibrate and statin + fibrate groups. High density
lipoprotein cholesterol and fasting blood glucose levels did not change in any
group. The levels of remnant like cholesterol particles decreased in the fibrate
and statin + fibrate groups. There was no change during the study in
the levels of creatine phosphokinase, lactate dehydrogenase, or creatinine. Conclusion: Combination statin and fibrate
therapy results in greater improvement in lipid profiles than monotherapy with
either drug. No marked adverse effects were observed with combination therapy during
the study.