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K. Sano, T. Nakamura, M. Hirano, Y. Kitta, T. Kobayashi, D. Fujioka, Y. Saito, T. Yano, K. Watanabe, Y. Watanabe, H. Mishina, J. Obata, K. Kawabata and K. Kugiyama, “Comparative Study of Bezafibrate and Pravastatin in Patients with Coronary Artery Disease and High Levels of Remnant Lipoprotein,” Circulation Journal, Vol. 74, No. 8, 2010, pp. 1644-1650.

has been cited by the following article:

• TITLE: Combination Lipid Therapy on Lipid Profiles in Patients with Impaired Glucose Tolerance

  AUTHORS: Hiroaki Kawano, Yasuhiro Nagayoshi, Hisao Ogawa, Yoshihiro Kinoshita

  KEYWORDS: Statins; Fibrates; Dyslipidemia

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.4 No.3, March 22, 2013

  ABSTRACT: Objective: This study compared the effects of combination statin and fibrate therapy with either statin or fibrate monotherapy on lipid profiles in patients with impaired glucose tolerance (IGT) and a high risk for cardiovascular disease. Methods & Patients: Forty-five patients with IGT and dyslipidemia (men 25, women 20, mean age 61.7 ± 2.4 yrs) were assigned randomly to the 3 treatment groups for a 6-month period. Results: After 6 months of treatment, low density lipoprotein levels decreased in every group, especially the statin and statin + fibrate groups. Triglyceride levels also decreased in all three groups, especially the fibrate and statin + fibrate groups. High density lipoprotein cholesterol and fasting blood glucose levels did not change in any group. The levels of remnant like cholesterol particles decreased in the fibrate and statin + fibrate groups. There was no change during the study in the levels of creatine phosphokinase, lactate dehydrogenase, or creatinine. Conclusion: Combination statin and fibrate therapy results in greater improvement in lipid profiles than monotherapy with either drug. No marked adverse effects were observed with combination therapy during the study.