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E. M. Lemmel, M. Franke, W. Gaus, P. W. Hartl, P. H. Hofschneider, K. Miehlke, K. Machalke and H. J. Obert, “Results of a Phase-II Clinical Trial on Treatment of Rheumatoid Arthritis with Recombinant Interferon-Gamma,” Rheumatology International, Vol. 7, No. 3, 1987, pp. 127-132. doi:10.1007/BF00270465

has been cited by the following article:

• TITLE: Amino Acid Composition Reduces Frequency of Common Colds. Results of a Controlled Randomised Completely Masked Trial

  AUTHORS: Alfons Meyer, Doris Meister, Wilhelm Gaus

  KEYWORDS: Amino Acids; Immune System; Vitamins; Common Cold; Chronic Infection of Ear Nose; Pharyngeal Area

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.3, March 19, 2013

  ABSTRACT: Purpose: Special nutrients have an impact on common cold infections. In this trial we have investigated the effectiveness of the specific amino acid composition “aminoplus? immun” on the occurrence, duration and severity of common cold. Material and Methods: Our study is a controlled, randomised completely masked trial comparing genuine trial remedy versus placebo in parallel groups. Eligible subjects were people with recurrent and chronic infections of the ear, nose and pharyngeal area. The treatment period was 90 days. The primary outcome was the mean number of days that the patients had symptoms of infections. Results: From Oct. 2009 to Feb. 2010 a total of 145 patients were recruited, of whom 119 had no major protocol violation and were valid for assessment. Two thirds of the patients were female. The mean age of the patients was 45 years. 65% of participants had come into contact with many people and thereby an increased risk of infection. On average the patients had 11.1 infections during the 12 months before the study. Compliance for the intake of the study preparation was 98.9%. Due to randomisation, the groups were very similar and balanced. The primary and all 6 secondary outcome variables showed a clear superiority of the investigated amino acid composition over placebo (p Conclusion: The specific composition “aminoplus? immun is effective in preventing recurrent and chronic infections of the ear, nose and upper respiratory tract.