TITLE:
Oral manifestations of acute promyelocytic leukemia: A case report
AUTHORS:
Daisuke Saito Daisuke Saito, Tadaharu Kobayashi, Yohei Oda, Kanae Niimi, Hiroyuki Kano, Chikara Saito
KEYWORDS:
Acute Promyelocytic Leukemia; OralManifestations; Oral Care
JOURNAL NAME:
Open Journal of Stomatology,
Vol.3 No.1,
March
18,
2013
ABSTRACT: Acuteleukemiaisoftenassociatedwithoralmanifestations.Wereportanacutepromyelocyticleukemia(APL)casewithoralmanifestationsleadingtothediagnosis. A21-year-oldfemale visitedourhospitalwithcomplaintsofgingivalbleedingandswellingoftheleftlowerwisdomtooth.Thepatient’scompletebloodcountrevealedamarkedincreaseinwhitebloodcellsandadecreaseinredbloodcellsandanabnormalleukocytedifferential,and APLwasdiagnosedonthebasisofbonemarrowsamples inthe internalmedicinedepartment.Thepatientwastreatedwithall-trans-retinoicacid combinedwithchemotherapyandhasmaintainedclinicalandmolecularcompleteremissionat12monthsoffollow-up. Dentalprofessionals shouldbeawareofclinicalmanifestationsandcomplicationsassociatedwith thesemalign-nantneoplasticdiseasestoaidindiagnosisandsubsequenttreatmentandmanagement.