TITLE:
The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome
AUTHORS:
Rebecca Allen, Shemoon Marleen, Luxmi Velauthar, Kevin Harrington, Joseph Aquilina
KEYWORDS:
AFP; Alpha Fetoprotein; Pre-Eclampsia; Small for Gestational Age; Still Birth; Placental Abruption
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.3 No.2,
March
13,
2013
ABSTRACT: Design: Retrospective analysis. Setting: East London Hospital. Subjects: 724 women who had maternal serum alphafetoprotein levels measured between 15 to 19 weeks gestation. Main outcome measure: The main outcome measures were defined as any case of preeclampsia, small-for-gestational age (SGA) birth- weight th centile, placental abruption, stillbirth or early neonatal death. Methods: Women with MSAFP > 2.0 Multiples of Median (MoM) were classified as screen positive. Results: 41 (5.7%) women developed preeclampsia. Women with MSAFP > 2.0 Multiples of the Median (MoM) were significantly more likely to develop preeclampsia (p th centile (p