TITLE:
Rapid Neurological Recovery Post Thrombolysis: Mechanisms and Implications
AUTHORS:
Bejoy Machumpurath, Maya Reddy, Bernard Yan
KEYWORDS:
Stroke; Tissue Plasminogen Activator; Thrombolysis; Recovery; Rapid Recovery; Clinical Predictors
JOURNAL NAME:
Neuroscience and Medicine,
Vol.4 No.1,
March
6,
2013
ABSTRACT: Intravenous
thrombolysis improves long term functional outcomes in acute ischemic stroke. A
select proportion of patients treated with
thrombolysis experience rapid early neurological recovery, a powerful predictor
of favourable long term outcomes. There is increased interest to augment early
neurological recovery by endovascular therapy or by adjuvant intravenous thrombolytics. However, incomplete
understanding of the physiological mechanisms of early recovery has hampered a
unified approach to monitor and to triage patients for invasive therapy. This
review aims to examine the current understanding and insights gained from recent
studies concerning early recovery and to inform the design of future studies.