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R. J. Hintz and K. C. Johnson, “The Effect of Particle Size Distribution on Dissolution Rate and Oral Absorp tion,” International Journal of Pharmaceutics, Vol. 51, No. 1, 1989, pp. 9-17. doi:10.1016/0378-5173(89)90069-0

has been cited by the following article:

• TITLE: Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation

  AUTHORS: R. Ravichandran

  KEYWORDS: Curcumin; Nanocrystal; Dissolution Evaluation

  JOURNAL NAME: Advances in Nanoparticles, Vol.2 No.1, February 28, 2013

  ABSTRACT: Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.