TITLE:
Anti free radical & anti inflammatory effect of rebamipide in chronic gastritis
AUTHORS:
Marcellus Simadibrata, Ari Fahrial Syam, Aziz Rani, Septelia Inawati Wanandi, Achmad Fauzi, Murdani Abdullah
KEYWORDS:
Rebamipide; Chronic Gastritis; Histopathologic Severity; MDA; Carbonyl Compound
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.3 No.1,
February
28,
2013
ABSTRACT: Background/Aim: Free radicals
have a role in the development of chronic gastritis. The aim of this study to know
the effect and efficacy of rebamipide on free radicals in chronic gastritis. Method:
Forty five patients in the division gastroenterology Cipto Mangunkusumo Hospital
Jakarta 2009-2010 with moderate and severe gastritis
endoscopically were included in this study. Before and after rebamipide treatment
the patient were performed endoscopical examination and were taken 5 biopsies for
histopathological examination and free radicals (MDA & Carbonyl Compound) examination.
All patients were given rebamipide 100 mg three times a day for 28 days. Data were
analyzed with t test or wilcoxon signed rank test. Exclusion: GERD, Peptic ulcer,
PPI treatment, NSAID consumption etc. The symptoms were recorded on day-0 and day-28.
The severity symptoms were measured by VAS. Result: The mucosal damage on day-0
was 2.268 ± 0.45 vs day-28 was 1.707 ± 0.78 (P P = 0.710) and corpus neutrophil:
day-0: 0.12 ± 0.40 vs day-28: 0.07 ± 0.26 (P = 0.421). The mean endoscopical
mucosal severity score was decreased significantly
on day- 28 compared to day-0 (1.707 ±
0.78 vs 2.268 ± 0.45; P P = 0.047).
The mean of carbonyl compound on day-0 was 4.14 ± 3.01 and on day-28 was 5.12 ±
2.71 (P = 0.642). Conclusion: Rebamipide significantly reduced the extend
of symptoms associated with chronic gastritis. The improvement in symptoms was associated
with the decreased of endoscopic severity score and the mean gastric mucosal malondialdehyde
(MDA) significantly but not the histopathologic appearance and carbonyl compound.