TITLE:
Therapy for H. pylori: Current concepts
AUTHORS:
Giulia Fiorini, Angelo Zullo, Valentina Castelli, Chiara Ricci, Giovanna Lo Re, Ilaria Saracino, Cristina Zaccaro, Federico Maria Verardi, Alessandra Reggi, Dino Vaira
KEYWORDS:
Helicobacter pylori; Sequential Therapy; Eradication
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.3 No.1,
February
28,
2013
ABSTRACT: Helicobacter pylori plays an important role in the pathogenesis of chronic
active gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue-lymphoma, and is also involved in carcinogenesis of the stomach. Since now no
current first-line therapy is able to cure the infection in all treated
patients. We evaluated data on the most successful therapy regimens—sequential,
concomitant and quadruple therapies—and on the standard therapy available for H. pylori eradication. When therapy
fails several factors may be involved: we reviewed both bacterial and host
factors that can affect the eradication and that can be involved in therapeutic
management of the H. pylori infection.