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Ghazaryan, S.H., Grigoryan, K.P., Ghevondyan, A.I., Minasyan, S.H., Tonoyan, V.C., Bajinyan, S.A., Pogho-syan A.S., Malakyan, M.H. and Sorensen, J. R. S. (2001) The synthesis of new derivatives of amino acids and pep-tides: Study of the radioprotective activity. 14th. Interna-tional Conference on Radiopharmaceutical Chemistry, Switzerland, 2001, 10-15.

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• TITLE: Zinc oxide nanocomposites with antitumor activity

  AUTHORS: Emma Arakelova, Ashot Khachatryan, Karapet Avjyan, Zoya Farmazyan, Alvard Mirzoyan, Lilia Savchenko, Sedrak Ghazaryan, Flora Arsenyan

  KEYWORDS: Zinc Oxide; Nanofilm; Magnetron Sputtering; Nanocomposites;Antitumor Activity

  JOURNAL NAME: Natural Science, Vol.2 No.12, December 28, 2010

  ABSTRACT: Zinc oxide nanocomposites in the form of coatings and composite films with antitumor activity were obtained by deposition of ZnO nanofilms on surfaces of ethyl ether Sali- cylidene DL-tyrosine (S1) and ethyl ether Sali- cylidene DL-tyrosine Cu (II) chelate (S2) by magnetron sputtering of Zn target. Ethyl ether salicylidene DL-tyrosine, Cu (II) chelate of ethyl ether salicylidene DL-tyrosine reveal some anticancer properties. Their zinc oxide nano- composites were obtained in the form of coat- ings (S1 + ZnO, S2 + ZnO) and composite films presenting a mixture of polyvinyl alcohol (PVA) with S1, S2 (S1 + PVA + ZnO, S2 + PVA + ZnO), for the purpose of increasing anticancer activity. Considerable increase in antitumor activity re- veal ZnO nanocomposites with salicylidene amino acid chelates (as distinct from their ethers) in the form of S2 + ZnO (47%) and S2 + PVA + ZnO (48%) in comparison with S2 (20%). Structural, spectral properties of the salicylidene amino acids and their ZnO nanocomposites were studied.