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Gould, K.L., Ornish, D., Kirkeeide, R., et al. (1992) Improved stenosis geometry by quantitative coronary arte riography after vigorous risk factor modification. American Journal of Cardiology, 69, 845-853. doi:10.1016/0002-9149(92)90781-S

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• TITLE: Ezetimibe Completely Replaced LDL-Apheresis for the Treatment of Familial Hypercholesterolemia and Coronary Artery Disease after CABG—A Case Report

  AUTHORS: Ikuo Yokoyama

  KEYWORDS: Ezetimibe; Familial Hypercholesterolemia; Statins; LDL-Apheresis; Coronary Artery Disease

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.2A, February 27, 2013

  ABSTRACT: Intensive treatment of hyperlipidemia is an important factor in the prevention of cardiovascular disease. Among several therapies, statins are well recognized as playing a central role, although low density lipoprotein bound cholesterol-apheresis can be used to treat very severe cases of familial hypercholesterolemia. However, statins are not always effective on their own and, recently, ezetimibe has emerged as a unique anti- hypercholesterolemic drug that acts as a cholesterol transporter inhibitor; its role is only partially understood. I experienced rare case that appeared to benefit from ezetimibe therapy, and report them as they help increase our knowledge of this novel drug.