TITLE:
Ezetimibe Completely Replaced LDL-Apheresis for the Treatment of Familial Hypercholesterolemia and Coronary Artery Disease after CABG—A Case Report
AUTHORS:
Ikuo Yokoyama
KEYWORDS:
Ezetimibe; Familial Hypercholesterolemia; Statins; LDL-Apheresis; Coronary Artery Disease
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.2A,
February
27,
2013
ABSTRACT: Intensive treatment of
hyperlipidemia is an important factor in the prevention of cardiovascular
disease. Among several therapies, statins are well recognized as playing a central role, although low density
lipoprotein bound cholesterol-apheresis can be used to treat very severe cases
of familial hypercholesterolemia. However, statins are not always effective on
their own and, recently, ezetimibe has emerged as a unique anti- hypercholesterolemic
drug that acts as a cholesterol transporter inhibitor; its role is only
partially understood. I experienced rare case that appeared to benefit from
ezetimibe therapy, and report them as they help increase our knowledge
of this novel drug.