TITLE:
Toward understanding the role of p53 in cardiovascular diseases
AUTHORS:
Mohanalatha Chandrasekharan, Silvia Vasquez, Rajesh Kumar Galimudi, Prashanth Suravajhala
KEYWORDS:
TP53, Cardiovascular Disease; Protein-Protein Interactions
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.2A,
February
27,
2013
ABSTRACT: Tumour
suppressor protein 53 (TP53 or simply p53) is a well known protein linked to
apoptosis, cell signalling, cascading and several myriad functions in cells.
Many diseases are linked to p53 though analysis show only 216 interaction
partners. Whether p53 plays an important role in cardiovascular diseases (CVD)
remains uncertain. Through this bioinformatical analysis, we propose that p53
might play a major role in CVD whilst being linked to Hypoxia and Lupus. There
could be evidence by pull down assay studies. Whether its interactants play a
role in CVD remains to be studied using experiments, though the interaction
maps show possible affect on other diseases.