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Shaheen, R.M., Davis, D.W., Liu, W., et al. (1999) Anti angiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Research, 59, 5412-5416.

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• TITLE: Monitoring vascular changes induced by photodynamic therapy using contrast-enhanced micro-computed tomography

  AUTHORS: Otilia C. Nasui, Stuart K. Bisland, Nancy L. Ford

  KEYWORDS: Micro-Computed Tomography; Contrast Agent; Animal Model; Photodynamic Therapy; Cancer

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.2, February 27, 2013

  ABSTRACT: The aim of this study was to determine whether contrast-enhanced micro-computed tomography can be used for non-invasive imaging of the early-stage changes in the vasculature of tumours that have been treated with photodynamic therapy (PDT). The subjects used were C3H mice with an RIF-1 tumour implanted subcutaneously and allowed to grow for 3 weeks prior to treatment. The experimental groups were PDT-treated (150 J/cm2 and 50 J/cm2) and control (150 J/cm2 light-only and untreated). The laser light exposure was performed at 15 - 30 minutes after the administration of the photosensitizer (BPD-MA). The contrast-enhanced micro-computed tomography imaging procedure consisted of eight-second scans taking place before treatment and up to 24 hours after treatment. The 150 J/cm2 PDT group showed a significant increase in the ratio of blood volume to tumour volume at 2, 8 and 24 hours after treatment when compared to pre-treatment measurements (p 2 PDT group at 24 hours after treatment. This preliminary study indicates that micro-CT can detect compromised vasculature in tumours treated with high-fluence photodynamic therapy as early as 2 hours post treatment.