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Banihashemi, B., Vlad, R., Debeljevic, B., et al. (2008) Ultrasound imaging of apoptosis in tumor response: Novel preclinical monitoring of photodynamic therapy effects. Cancer Research, 68, 8590-8596. doi:10.1158/0008-5472.CAN-08-0006

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• TITLE: Monitoring vascular changes induced by photodynamic therapy using contrast-enhanced micro-computed tomography

  AUTHORS: Otilia C. Nasui, Stuart K. Bisland, Nancy L. Ford

  KEYWORDS: Micro-Computed Tomography; Contrast Agent; Animal Model; Photodynamic Therapy; Cancer

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.2, February 27, 2013

  ABSTRACT: The aim of this study was to determine whether contrast-enhanced micro-computed tomography can be used for non-invasive imaging of the early-stage changes in the vasculature of tumours that have been treated with photodynamic therapy (PDT). The subjects used were C3H mice with an RIF-1 tumour implanted subcutaneously and allowed to grow for 3 weeks prior to treatment. The experimental groups were PDT-treated (150 J/cm2 and 50 J/cm2) and control (150 J/cm2 light-only and untreated). The laser light exposure was performed at 15 - 30 minutes after the administration of the photosensitizer (BPD-MA). The contrast-enhanced micro-computed tomography imaging procedure consisted of eight-second scans taking place before treatment and up to 24 hours after treatment. The 150 J/cm2 PDT group showed a significant increase in the ratio of blood volume to tumour volume at 2, 8 and 24 hours after treatment when compared to pre-treatment measurements (p 2 PDT group at 24 hours after treatment. This preliminary study indicates that micro-CT can detect compromised vasculature in tumours treated with high-fluence photodynamic therapy as early as 2 hours post treatment.