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M. D. Holder, “Responsivity to Pain in Rats Changed by the Ingestion of Flavoured Water,” Behavioral and Neural Biology, Vol. 49, No. 1, 1988, pp. 45-53. doi:10.1016/S0163-1047(88)91207-1

has been cited by the following article:

• TITLE: Assessing the Analgesic Effects of Sucrose to Cold Pressor Pain in Human Adults

  AUTHORS: Michele E. Mercer, Mark D. Holder

  KEYWORDS: Sucrose; Analgesia; Pain; Cold Pressor; Humans

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.3 No.1, February 26, 2013

  ABSTRACT: Previous studies report that the ingestion of highly concentrated sweet solutions produces a morphine-like analgesia in rats, human infants, and in adult males. To determine whether sweet-induced analgesia occurs with more commonly consumed substances, 30 adult males (Mage = 22.4 years) were exposed to a cold pressor test and pain responsivity was assessed both before and after consuming either an 8% sucrose solution, water, or nothing. Between-groups comparisons revealed that relative to the Sucrose or Nothing groups, the Water group showed increased pain tolerance. Neither pain thresholds nor ratings of pain intensity and unpleasantness on a visual analogue scale differed among groups. The results support previous findings in both humans and animals that the palatability or hedonic value of food or drink may be the key predictor of its analgesic effect.