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D. Wouters, P. van Schouwenburg, A. van der Horst, M. de Boer, D. Schooneman, T. W. Kuijpers, et al., “High Throughput Analysis of the C4 Polymorphism by a Com bination of MLPA and Isotype Specific ELISA’s,” Mo lecular Immunology, Vol. 46, No. 4, 2009, pp. 592 600. doi:10.1016/j.molimm.2008.07.028

has been cited by the following article:

• TITLE: Low Levels of Complement Factor C4 Not Always Implicate Disease Activity in Systemic Lupus Erythematosus

  AUTHORS: E. J. ter Borg, H. van Velzen-Blad, D. Hamann

  KEYWORDS: Complement; Homozygous C4A Isotype Deficiency; Systemic Lupus Erythematosus

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.4 No.2, February 26, 2013

  ABSTRACT: A lupus patient with a clinically quiescent disease stage will be described who had severely depressed C4 levels while levels of C3 en CH50 were normal. Additional testing revealed a homozygous C4Aisotype deficiency as the cause of the very low C4 levels. It should be emphasized that in SLE, a (very) low C4 level does not always means (subclinical) disease activity.