Gosalvez, M. (2012) Reversal of cancer by dual strategy: A new molecular target? Proceedings 103rd AACR Meeting, Chicago, 31 March-4 April 2012, Abstract 4611, 1118.
has been cited by the following article:
TITLE: Metabolic control of respiration and glycolysis of tumoral cells
AUTHORS: Mario Gosalvez
KEYWORDS: Energy Metabolism; Cancer; Mitochondrial Filamentation; Glycolysis; Respiration; Metabolic Control
JOURNAL NAME: Advances in Biological Chemistry, Vol.3 No.1, February 26, 2013
ABSTRACT: The contribution of the author’s groups on the control of energy metabolism of cancer cells has been concisely reviewed. It is proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in an alteration of the recurrent filamentation cycle of mitochondria. These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells.