TITLE:
Metabolic control of respiration and glycolysis of tumoral cells
AUTHORS:
Mario Gosalvez
KEYWORDS:
Energy Metabolism; Cancer; Mitochondrial Filamentation; Glycolysis; Respiration; Metabolic Control
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.1,
February
26,
2013
ABSTRACT: The contribution of the author’s groups on the control
of energy metabolism of cancer cells has been concisely reviewed. It is
proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in
an alteration of the recurrent filamentation cycle of mitochondria. These give
those organelles an affinity lower for ADP than the affinity of the tumor cell
isoenzyme of pyruvate kinase. These two findings may explain the essentials of
the intimate mechanism of the aerobic glycolysis of cancer cells.