TITLE:
Use of Solid-Supported Reagents towards Synthesis of 2-Arylbenzoxazole, 3, 5-Diarylisoxazole and 1, 3, 5-Triarylpyrazole
AUTHORS:
Sneha Naik, Vidya Desai
KEYWORDS:
Schiff’s Bases; 3, 5-Diarylisoxazoles; 2-ArylBenzoxazoles; 1, 3, 5-Triaryl Pyrazoles; Solid-Supported Reagents
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.3 No.1,
February
25,
2013
ABSTRACT: Herein we report a convenient and efficient synthesis of
2-Arylbenzoxazole from the Schiff’s bases of 2-Aminophenol, 3, 5-Diarylisoxazole
from α, β-unsaturated ketoxime and 1,3,5-Triarylpyrazole from 2-pyrazoline
and N-Arylhydrazone by using milder, less toxic and less expensive-NBS-SiO2,
KMnO4-Al2O3, PCC-SiO2 and ACC-Al2O3 as solid-supported oxidizing agents at room temperature. Within the framework
of Green Chemistry, the use of solid supported reagents has many advantages
such as 1) they are easy to remove from reactions by filtration 2) excess
reagents can be used to drive the reaction without introducing any difficulties
in purification 3) such solid-supported reagents react differently, mostly
more selectively, than their unbound counterparts and 4) toxic, noxious
and explosive chemicals are handled more safely when contained on solid
support.