TITLE:
Neuropsychiatric Systemic Lupus Erythematosus Complicated with Acute Pericarditis in Patient with Hyperprolactinaemia: A Case Report
AUTHORS:
Caterina Naclerio, Giovanna Cuomo, Gabriele Valentini
KEYWORDS:
Systemic Lupus Erythematosus; Neuropsychiatric Systemic Lupus Erythematosus; Psychosis; Pericarditis; C4 Level; Prolactin
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.3 No.1,
February
18,
2013
ABSTRACT:
Neuropsychiatric systemic lupus erythematosus (NP-SLE) is one of the major cause of morbidity in systemic lupus erythematosus patients and its treatment depends on identification of pathogenic mechanisms. We describe the rare case of neuropsychiatric systemic lupus erythematosus (NP-SLE) complicated by pericardial effusion combined to low C4 level persisting and hyperprolactinaemia. A cyclophosphamide therapy showed a good response in a 21-year old woman with disturbances in thought processes and an acute confusional state with sierositis. This paper confirms that a cyclophosphamide therapy contributes to control a disease activity by a mechanism of prolactin level reduction. Other studies occur to evaluate this hypothesis.