TITLE:
The association of adenosine deaminase with coronary artery disease: Effect of gender and diabetes
AUTHORS:
Fulvia Gloria-Bottini, Krzysztof Safranow, Maria Banci, Agnieszka Binczak-Kuleta, Patrizia Saccucci, Andrzej Ciechanowicz, Andrea Magrini, Zdzislawa Kornacewicz-Jach, Egidio Bottini, Dariusz Chlubek
KEYWORDS:
ADA; CAD; Gender; Diabetes
JOURNAL NAME:
Health,
Vol.5 No.2,
February
17,
2013
ABSTRACT: An association between ADA1 and Coronary Artery Disease (CAD) has been observed in Polish and in Italian
populations but in Italian population the association was present in males
only. In order to enlighten these differences we have carried out a
collaborative study in the two populations. In Italy 215 subjects admitted to
the Hospital for CAD, 275 subjects with Type 2 Diabetes (T2D) without CAD and
398 healthy new-borns were studied. In Poland 173 subjects with CAD and 200
healthy newborns were studied. Written informed consent was obtained from all subjects
or from their mothers to participate to the study that was approved by the
I.R.B. ADA1 polymorphism was determined by DNA analysis. Three way
contingency table analysis was performed by a log linear model. The association
between CAD and ADA1 is present in non diabetic male subjects
only: OR = 0.195, p = 0.007 in the Italian population and OR = 0.163, p = 0.004
in the Polish population. The data suggest a significant role of
immunological mechanisms in the pathogenesis of CAD without diabetes. Gender
differences in immune diseases could explain the lack of association in
females.