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M. Notarbartolo, P. Poma, D. Perri, L. Dusonchet, M. Cervello and N. D’Alessandro, “Antitumoreffects of Curcumin, Alone or in Combination with Cisplatin or Doxorubicin, on Humanhepaticcancer Cells. Analysis of Their Possiblerelationship to Changes in NF-kB Activation Levels and in IAP Gene Expression,” Cancer Letters, Vol. 224, No. 1, 2005, pp. 53-65. doi:10.1016/j.canlet.2004.10.051

has been cited by the following article:

• TITLE: Synthesis and Anticancer Activity of Mono-Carbonyl Analogues of Curcumin

  AUTHORS: Song Yin, Xing Zheng, Xu Yao, Yuhong Wang, Duanfang Liao

  KEYWORDS: Curcumin; Mono-Carbonyl Analogues; Anticancer Activity; SAR

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.1, February 7, 2013

  ABSTRACT: Curcumin has been reported to possess multifunctional bioactivities with low toxicity. However, the clinical application of curcumin has been significantly limited by its instability and poor metabolic property. Up to now, multiple approaches are being sought to overcome these limitations to obtaining “super curcumin”, and many analogues of curcumin have been designed and synthesized. In all of those analogues, a series of mono-carbonyl curcumin analogues deleting the β-diketone draw our attention. Since the seven-carbon β-diketone linker in curcumin may be responsible for its instability, the series of mono-carbonyl curcumin analogues deleting the β-diketone may be potential prodrug with improved pharmacokinetic and pharmacodynamic properties. This review just focuses on these more stable mono-carbonyl analogues of curcumin, and shows the new class of active structure by introducing the synthesis and anticancer activity of them.