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Samanta, A.K., et al.(2004) Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. J Biol Chem, 279(9): p. 7576-83.

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• TITLE: Isoform Inference From RNA-Seq Samples Based on Gene Structures on Chromosomes

  AUTHORS: Yan Ji, Jia Wei

  KEYWORDS: RNA-Seq; isoform inference; cancer genes; Cufflinks; RSEM

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.1 No.1, February 6, 2013

  ABSTRACT: The emerging RNA-Seq technology makes it possible to infer splicing variants from millions of short sequence reads. Here we present a method to identify isoforms by their specific signatures on chromosomes including both exons and junctions. By applying this method to a RNA-Seq dataset of gastric cancer, we showed that our method is more accurate and sensitive than other isoform inference tools such as RSEM and Cufflinks. By constructing a network from gene list identified by our method but missed by other tools, we found that some cancer-related genes enriched in network modules have significant implications for cancer drug discovery.