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F. Tárkányi, A. Hermanne, S. Takacs, F. Ditrói, B. Király et al., “Experimental Study of the 165Ho(p,n) Nuclear Reaction for Production of the Therapeutic Radioisotope 165Er,” Nuclear Instruments and Methods in Physics Research, Section B, Vol. 266, No. 15, 2008, pp. 3346-3352.

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• TITLE: Nuclear Model Calculations on the Production of Auger Emitter 165Er for Targeted Radionuclide Therapy

  AUTHORS: Mahdi Sadeghi, Milad Enferadi, Claudio Tenreiro

  KEYWORDS: 165Er, Auger Electron, Excitation Functions, TALYS-1.2, ALICE-ASH

  JOURNAL NAME: Journal of Modern Physics, Vol.1 No.4, December 6, 2010

  ABSTRACT: Auger electron emitting radionuclides have potential for the therapy of small-size cancers because of their high level of cytotoxicity, low-energy, high linear energy transfer, and short range biologic effectiveness. Auger emitter 165Er (T1/2 = 10.3 h, IEC = 100%) is a potent nuclide for targeted radionuclide therapy. 165Er excitation function via 165Ho(p,n)165Er, 165Ho(d,2n)165Er, 166Er(p,2n)165Tm→165Er, 166Er(d,3n)165Tm→165Er, natEr(p,xn)165Tm→165Er and 164Er(d,n)165Tm→165Er reactions were calculated by ALICE/91, ALICE/ASH (GDH Model & Hybrid Model) and TALYS-1.2 (Equilibrium & Pre-Equilibrium) codes and compared to existing data. Requisite for optimal thicknesses of targets were obtained by SRIM code for each reaction.