TITLE:
Bacterial Cells as Model Factories
AUTHORS:
Ichiro Matsumura
KEYWORDS:
Complex Systems; Control Theory; Synthetic Biology; Metabolic Engineering
JOURNAL NAME:
American Journal of Operations Research,
Vol.3 No.1A,
January
30,
2013
ABSTRACT: Bacteria, like industrial engineers, must manage processes that convert low value inputs into high value outputs. Bacteria are not intelligent, so they utilize self-organizing production systems to accelerate life-sustaining chemical processes. Here I explore two questions. First, can businesses apply the principles of self-organization? Second, can operations researchers contribute to our understanding of biological systems? I explain biochemical concepts in plain terms, illustrated with a few informative laboratory evolution experiments, and describe the organizing principles that underlie complex biological systems. I describe the new disciplines of synthetic biology and metabolic engineering, which offer opportunities for interdisciplinary collaboration between life scientists and operations researchers.