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I. D. Xynos, A. J. Edgar, L. D. K. Buttery, L. L. Hench and J. M. Polak, “Gene-Expression Profiling of Human Osteoblasts Following Treatment with Ionic Products of Bioglass? 45S5 Dissolution,” Journal of Biomedical and Materials Research, Vol. 55, No. 2, 2001, pp. 151-157. doi:10.1002/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D

has been cited by the following article:

• TITLE: Sol-Gel Synthesis of SiO2-CaO-Na2O-P2O5 Bioactive Glass Ceramic from Sodium Metasilicate

  AUTHORS: Luqman A. Adams, Enobong R. Essien, Rafiu O. Shaibu, Aderemi Oki

  KEYWORDS: Bioative Glass; Sol-Gel; Crystalline; Sodium Metasilicate; Hydroxyapatite

  JOURNAL NAME: New Journal of Glass and Ceramics, Vol.3 No.1, January 29, 2013

  ABSTRACT: Bioactive glass ceramic with SiO2-Ca2O-Na2O-P2O5 composition was prepared by the sol-gel method using sodium metasilicate (Na2SiO3) as silica source. The monolith obtained was sintered at 1000?C for 2 hours after which X-ray diffraction (XRD) analysis showed presence of combeite (Na2Ca2Si3O9) as the crystalline phase. In vitro bioactivity test conducted on the material using simulated body fluid (SBF) showed the formation of carbonated hydroxyapatite on its surface. The material during the SBF test was observed to transform from a mechanically strong crystalline phase Na2Ca2Si3O9 to an amorphous phase after incubation for 14 days indicating that the material was biodegradable. Scanning electron microscopy (SEM) was used to investigate the surface morphology, while Fourier transform infrared (FTIR) spectroscopy facilitated the confirmation of hydroxyapatite (HA) formation. The monolith material obtained may be a good candidate for application in tissue engineering scaffolds.